22 May 2013 Last updated at 16:54 GMT
He will answer questions put to him by a live audience of young people from all over Africa.
And he will take questions sent in by BBC viewers and listeners from around the world. HARDtalk’s Zeinab Badawi will host this special event in Ethiopia’s capital Addis Ababa on Sunday, 26 May 2013.
Mr Kerry’s trip to Africa comes as the African Union celebrates 50 years.
HARDtalk special with John Kerry
- BBC World 0330 GMT, 0830 GMT, 1430 GMT and 2030 GMT on Tuesday 28 May 2013
- BBC News Channel 0430 GMT on Tuesday 28 May and 0030 GMT on Wednesday 29 May 2013
- BBC Two 1020 GMT on Tuesday 28 May
- BBC World Service from 0400 GMT Wednesday 28 May
The organisation is holding a summit in Addis Ababa as part of the commemoration.
The week-long trip also takes Mr Kerry to the Middle East. He is hoping to help find solutions for both the Syrian and Palestinian-Israeli conflicts.
This is your chance to ask the US Secretary of State your question about Africa, United States foreign policy and about his country’s relationship with the rest of the world.
The special HARDtalk programme will be broadcast on BBC World, News Channel and BBC Two on Tuesday 28 May and on World Service Radio on Wednesday 29 May 2013.
Tweet your question incorporating the hashtag #hardtalk #youthconnect or email your question to email@example.com by Saturday, 25 May 2013.